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TIDAL: Target-Induced Droplet Assembly of Ligands

Special Notice monitored from sam-gov.

Buyer / agency
ENERGY, DEPARTMENT OF
Notice type
Special Notice
Solicitation number
S-197478
Posted
September 8, 2026
Response deadline
December 9, 2026
Location
NM, US
Estimated value
Not published by the source
NAICS
541714
Source
sam-gov

Summary

Developed by Los Alamos National Laboratory, TIDAL (Target-Induced Droplet Assembly of Ligands) transforms the small antibody fragments known as nanobodies into a programmable, protein-only material that organizes itself on demand. By harnessing a natural process called liquid-liquid phase separation, TIDAL lets these binders gather into dense, dynamic droplets precisely when they encounter their intended target, giving developers a single platform that can purify proteins wi…

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Summaries are indexed from official public sources; the issuing platform’s notice, documents, and amendments always control.